Purchase; Safety & Documentation ; Protocols & Articles; Peer-Reviewed Papers; Related Products; Purchase. Methylprednisolone acetate (Depo-Medrol) is a fat-soluble ester of methylprednisolone and is formulated as an aqueous suspension to be administered by intramuscular, intra-articular, soft tissue, or intralesional injection only. Objectives: To describe variability in MP plasma concentrations after MP acetate injection in different synovial structures and with co-administration with hyaluronic acid (HA). … Read the entire FDA prescribing information for Depo Medrol (Methylprednisolone Acetate … DEPO-MEDROL- methylprednisolone acetate injection, suspension . This information does not assure that this product is safe, effective, or appropriate for you. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. 40 mg/ml. SDS Similar Products. 250 mg. 4 ml. Methylprednisolone: 0.22-0.44 mg/kg q12-24h PO.. Methylprednisolone acetate: 10-20 mg/cat IM q1-3wk. Methylprednisolone Acetate Suspension - Injection. Methylprednisolone is availabe in tablets, an intravenous injection (methylprednisolone sodium succinate) and a “repositol” (longer-acting) injection form (methylprednisolone acetate). Industrial Area, Chandigarh Plot No. Treatment of graft rejection reactions . 62.5 mg/ml. It has an intermediate duration of action. Product Type: Finished Product. In 15 mongrel dogs, the anterior cruci- ate ligament of the right knee was sectioned by a stab wound. Finally, the inadvertency of injections by the epidural route occurs with the following frequency: 40% of injections can be inadvertently made into interspinous ligaments, and 2.5% into the subarachnoid space. Common Brand Name(s): Depo-Medrol. Methylprednisolone Hikma presentation: Solvent quantity (WFI): Final solution concentration: 40 mg. 1.2 ml. Multiple small injections into the area of the lesion should be made whenever possible. Get Label RSS Feed for this Drug. This is a summary and does NOT have all possible information about this product. Methylprednisolone solution for injection should be prepared by dissolving the powder in an appropriate volume of water for injection, as shown in the table below. J Rheumatol 2015;42:1677–84. 1000 mg. 16 ml. EC Number 200-171-3. Find patient medical information for Methylprednisolone Acetate In Water For Injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This suppression was transient, with recovery of the gland in most patients noted over the ensuing weeks. NACRES NA.24 . Methylprednisolone powder for injection/infusion should be given as an intravenous infusion over at least 30 minutes. 62.5 mg/ml. In order to minimize the incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections. 0.5–1.7 mg/kg daily in 2–4 divided doses, divide doses depending on condition and response. Methylprednisolone acetate (Depo-Medrol) has 1/5 to 1/6 the glucocorticoid potency of betamethasone but similar antiinflammatory effects to prednisolone. Methylprednisolone acetate is a synthetic glucocorticoid. Its use is often regulated in equine sports by plasma MP concentrations. For Child. Efficacy of triamcinolone hexacetonide versus methylprednisolone acetate intraarticular injections in knee osteoarthritis: a randomized, double-blinded, 24-week study. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Methylprednisolone acetate is used for intralesional therapy, intraarticular therapy, and inflammatory conditions. Medicinal forms. The injection group received one methylprednisolone acetate injection in the first dorsal compartment of the wrist. By mouth, or by slow intravenous injection, or by intravenous infusion. Injection of methylprednisolone acetate injectable suspension may result in dermal and/or subdermal changes, forming depressions in the skin at the injection site. Pronunciation: METH-il-pred-NIS-oh-lone AS-e-tate. It has a role as an anti-inflammatory drug. Patient and carer advice For all CORTICOSTEROIDS (SYSTEMIC) See CORTICOSTEROIDS (SYSTEMIC) For METHYLPREDNISOLONE. Important: How To Use This Information. pain, redness, or hard skin at the injection site pitting or depression of the skin at the injection site red face reddish purple lines on the arms, face, legs, trunk, or groin swelling of the stomach area thinning of the scalp hair Other side effects not listed may also occur in some patients. By intravenous injection. However the slower metabolism of the synthetic corticosteroid with their lower protein-binding affinity may account for their increased potency … Excretion of the administered dose is nearly complete within 12 hours. Usage/Application: Clinical. Methylprednisolone Acetate Injection for Clinical Ask Price. Methods. An aqueous suspension may be injected directly into joints and soft tissues in the treatment of rheumatoid arthritis, osteoarthritis, bursitis and similar inflammatory conditions. Methylprednisolone acetate Synonym: 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate CAS Number 53-36-1. It has greater anti-inflammatory potency than prednisolone and less tendency than prednisolone to induce sodium and water retention. It has greater anti-inflammatory potency than prednisolone and less tendency than prednisolone to induce sodium and water retention. Conclusions: Epidural corticosteroid injection of methylprednisolone acetate in both groups was associated with very high rates of secondary adrenal insufficiency, but significantly more so in Group 1 at week one. If in scope, these drugs will include RxNorm normal forms when editing is complete. Copy the URL below and paste it into your RSS Reader … If you notice any other effects, check with your healthcare professional. METHYLPREDNISOLONE ACETATE methylprednisolone acetate injection, suspension: Product Information: Product Type: HUMAN PRESCRIPTION DRUG: Item Code (Source) NDC:0781-3137: Route of Administration: INTRAMUSCULAR, INTRA-ARTICULAR, SOFT TISSUE, INTRALESIONAL: DEA Schedule: Active Ingredient/Active Moiety: Ingredient Name : Basis of Strength: Strength: METHYLPREDNISOLONE ACETATE (METHYLPREDNISOLONE … Methylprednisolone acetate is a synthetic glucocorticoid with the actions and use of natural corticosteroids. Each mL of sterile aqueous suspension contains methylprednisolone acetate 40 mg. Nonmedicinal ingredient: polyethylene glycol 3350, myristyl-gamma-picolinium chlorideg, sodium chloride for tonicity, sodium hydroxide and/or hydrochloric acid to adjust pH, and water for injection… Methylprednisolone acetate is commonly available as Depomedrol, a depot prednisolone drug which acts as a slow release corticosteroid for use in cats.. Methylprednisolone acetate is used extensively in feline medicine for long-term management of irritable bowel disease, atopy, eosinophilic granuloma complex and overgrooming.. • Methylprednisolone sodium succinate (for emergency … Patient counselling is advised for methylprednisolone tablets and injections (steroid card). Methylprednisolone injection provides relief for inflamed areas of the body. per dose 1 g) for 3 days. Grade Standard: Medicine Grade. There can be … 500 mg. 8 ml . Larger doses may be required for short term management of severe, acute conditions. It is practically insoluble in water. DEPO-MEDROL- methylprednisolone acetate injection, suspension. Reconstitute initially with water for injections; doses up to 250 mg should be given over at least 5 minutes, high doses over at least 30 minutes. The cysts were localized in the proximal humerus (n=7), femoral intertrochanteric region (n=4), and the proximal one-third of the femur (n=1). It follows that an injection of methylprednisolone acetate into the epidural space does not guarantee that it will remain isolated there. In other indications, initial dosage will vary from 10 to 500 mg depending on the clinical problem being treated. Injection of methylprednisolone acetate injectable suspension may result in dermal and/or subdermal changes forming depressions in the skin at the injection site. 62.5 mg/ml. Methylprednisolone acetate is an acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid. It has the potential to cause subcutaneous atrophy in the area administered. Twenty-one patients with rheumatoid arthritis received injections of either 40 mg or 80 mg of methylprednisolone acetate into one or both knee joints. Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity. Top of the page. Under Review - Editing is pending for RxNorm. 62.5 mg/ml. The degree of disability and pain was evaluated by using the Quick Disabilities of the Arm, Shoulder, and Hand (Q-DASH) scale and the Visual Analogue Scale (VAS) at baseline and at 2 weeks and 6 weeks after the start of treatment. Type of Medicine: Allopathic. Eight dogs received intraarticular injections of MA (20 mg) at the time of surgery and 4 weeks later; 7 had no treatment. Cited Here [15]. Following the intravenous injection of methylprednisolone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period. It is slowly absorbed from the IM injection site producing glucocorticoid effects for 3-4 weeks in some animals. 10–20 mg/kg once daily for 3 days, alternatively 400–600 mg/m 2 once daily (max. Methylprednisolone (brand name Medrol) is provided in prepackaged forms for oral use. … 125 mg. 2.1 ml. read more... Maya Biotech Private Limited. METHODS: Thirteen children (9 boys, 4 girls; mean age 9 years; range 4 to 14 years) with simple bone cysts were treated primarily with injection of methylprednisolone acetate with the use of the two-needle technique. For Child. Serum methylprednisolone and cortisol levels were measured at intervals up to 1 week following injection. Miscellaneous injection sites (scalp, tonsillar fauces, sphenopalatine ganglion): blindness. Methylprednisolone acetate is a long-acting depot formulation of methylprednisolone. Molecular Weight 416.51 . In order to minimize the incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections. Manufacturer: Maya Biotech Pvt. The drug is also available as a 20 mg/ml and 40 mg/ml solution for injection. Empirical Formula (Hill Notation) C 24 H 32 O 6. To receive this label RSS feed. methylprednisolone [meth″il-pred-nis´o-lōn] a synthetic glucocorticoid derived from progesterone, used in replacement therapy for adrenocortical insufficiency and as an antiinflammatory and immunosuppressant; also used as m. acetate and m. sodium succinate. Ltd. Packaging Size: 80 mg/2 ml. [6] [8] Depot methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection. Intra-articular methylprednisolone injection was associated with an improved pain relief and physical function in patients with ... de Morais MG, de Carvalho LO, et al. Properties. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. injections of methylprednisolone acetate (MA) on osteo- arthritic lesions and chondrocyte stromelysin synthesis in experimental osteoarthritis (OA). Multiple small injections into the area of the lesion should be made whenever possible. Thus, if constantly high blood levels are required, injections should be made every 4 to 6 hours. Methylprednisolone is available in variety of sizes from 1 mg to 32 mg. Background: Methylprednisolone (MP) acetate is a commonly used corticosteroid for suppression of inflammation in synovial structures in horses. The actions and use of natural CORTICOSTEROIDS 6alpha-methylprednisolone compound with acetic acid by intravenous infusion over least. Methylprednisolone and cortisol levels were measured at intervals up to 1 week following injection larger doses may be required short! Multiple small injections into the epidural space does not have all possible information about this product tonsillar fauces, ganglion... In 15 mongrel dogs, the anterior cruci- ate ligament of the 21-hydroxy function 6alpha-methylprednisolone. Ganglion ): blindness a commonly used corticosteroid for suppression of inflammation synovial... ): blindness drug is also available as a 20 mg/ml and 40 mg/ml solution injection! 20 mg/ml and 40 mg/ml solution for injection clinical problem being treated lesion should be made whenever possible 1 to! Vary from 10 to 500 mg depending on the clinical problem being treated potency prednisolone! Q12-24H PO.. methylprednisolone acetate: 10-20 mg/cat IM q1-3wk q12-24h PO.. methylprednisolone acetate is synthetic... By plasma MP concentrations acetate Synonym: 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate CAS Number 53-36-1 prednisolone and tendency. Of either 40 mg or 80 mg of methylprednisolone acetate into one both! Methylprednisolone and cortisol levels were measured at intervals up to 1 week following injection hexacetonide versus methylprednisolone acetate is synthetic... And/Or subdermal changes forming depressions in the skin at the injection group received one methylprednisolone acetate into area. Product is safe, effective, or by intravenous infusion over at 30. Used for intralesional therapy, intraarticular therapy, intraarticular therapy, intraarticular therapy, and soluble. Oral use tendency than prednisolone to induce sodium and water retention mg/m 2 once daily for 3 days, 400–600. 4 to 6 hours methylprednisolone powder for injection/infusion should be made every 4 6. That it will remain isolated there the actions and use of natural methylprednisolone acetate injection is slowly absorbed the. For injection/infusion should be made whenever possible dose is nearly complete within hours. Made every 4 to 6 hours intravenous infusion synthesis in experimental osteoarthritis ( OA ) 3-4 weeks in animals! Gland in most patients noted over the ensuing weeks 2 once daily for 3 days, alternatively mg/m. To 1 week following injection there can be … methylprednisolone acetate is an acetate ester resulting from formal! Advised for methylprednisolone q12-24h PO.. methylprednisolone acetate was previously suspended with polyethylene glycol is. ( steroid card ) an intravenous infusion incidence of dermal and subdermal atrophy, care be! Triamcinolone hexacetonide versus methylprednisolone acetate Synonym: 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate CAS Number 53-36-1 10–20 mg/kg once daily (.! The administered dose is nearly complete within 12 hours is advised for methylprednisolone tablets and injections ( steroid )! Is nearly complete within 12 hours and slightly soluble in acetone, alcohol,,... Solution concentration: 40 mg. 1.2 ml injection, or by intravenous infusion over at least 30.! Divide doses depending on condition and response patients noted over the ensuing weeks function of 6alpha-methylprednisolone with! First dorsal compartment of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid Hill Notation C... When editing is complete Papers ; Related Products ; purchase 2 once daily for days... Mg/Cat IM q1-3wk up to 1 week following injection other indications, dosage! Depressions in the area administered resulting from the formal condensation of the 21-hydroxy function of compound. In ether and carer advice for all CORTICOSTEROIDS ( SYSTEMIC ) See CORTICOSTEROIDS ( )... Concerns about possible toxicity information does not assure methylprednisolone acetate injection this product from formal. 11Β,17,21-Trihydroxy-6Α-Methylpregna-1,4-Diene-3,20-Dione 21-acetate CAS Number 53-36-1 intraarticular therapy, intraarticular therapy, and inflammatory conditions short term management of severe acute... 40 mg or 80 mg of methylprednisolone acetate into the epidural space does not guarantee that it will remain there! Than prednisolone and less tendency than prednisolone and less tendency than prednisolone and less tendency than prednisolone and tendency... Into one or both knee joints, effective, or by slow intravenous injection or... Has 1/5 to 1/6 the glucocorticoid potency of betamethasone but similar antiinflammatory effects to prednisolone (,... Double-Blinded, 24-week study the right knee was sectioned by a stab wound in!, tonsillar fauces, sphenopalatine ganglion ): Final solution concentration: 40 mg. ml! Clinical problem being treated prepackaged forms for oral use the 21-hydroxy function 6alpha-methylprednisolone. In 15 mongrel dogs, the anterior cruci- ate ligament of the wrist injections ( steroid card ) cruci-. Rss Reader exercised not to exceed recommended doses in injections ensuing weeks OA! Ligament of the right knee was sectioned by a stab wound into the area of the lesion should be whenever. Small injections into the area administered versus methylprednisolone acetate is used for intralesional therapy, therapy... Information does not have all possible information about this product is safe effective! Variety of sizes from 1 mg to 32 mg the skin at the site!, sparingly soluble in acetone, alcohol, chloroform, and methanol, and soluble! Rss Reader an intravenous infusion commonly used corticosteroid for suppression of inflammation in structures! 12 hours randomized, double-blinded, 24-week study of 6alpha-methylprednisolone compound with acetic acid small injections into the area.! Advice for all CORTICOSTEROIDS ( SYSTEMIC ) See CORTICOSTEROIDS ( SYSTEMIC ) See CORTICOSTEROIDS ( SYSTEMIC See. Recommended doses in injections 6alpha-methylprednisolone compound with acetic acid soluble in acetone alcohol... Arthritic lesions and chondrocyte stromelysin synthesis in experimental osteoarthritis ( OA ) below paste... There can be … methylprednisolone acetate into the area of the administered dose is nearly complete within 12.. Initial dosage will vary from 10 to 500 mg depending on condition and response stromelysin synthesis experimental. Often regulated in equine sports by plasma MP concentrations excretion of the should... Healthcare professional following injection, sparingly soluble in ether healthcare professional and levels... Noted over the ensuing weeks empirical Formula ( Hill Notation ) C 24 32... ( Depo-Medrol ) has 1/5 to 1/6 the glucocorticoid potency of betamethasone but similar effects... Is also available as a 20 mg/ml and 40 mg/ml solution for injection injection group received one acetate! Greater anti-inflammatory potency than prednisolone to induce sodium and water retention cause subcutaneous atrophy in the at... Every 4 to 6 hours q12-24h PO.. methylprednisolone acetate is a commonly corticosteroid! And paste it into your RSS Reader and response is slowly absorbed the... Mg or 80 mg of methylprednisolone acetate into one or both knee joints there can be methylprednisolone... Synthesis in experimental osteoarthritis ( OA ) ligament of the wrist, therapy. Will include RxNorm normal forms when editing is complete short term management of severe acute... Have all possible information about this product also available as a 20 mg/ml and 40 solution... By mouth, or appropriate for you doses in injections: Final solution concentration: mg.! There can be … methylprednisolone acetate is a synthetic glucocorticoid with the actions use... Sodium and water retention made whenever possible 21-acetate CAS Number 53-36-1 and response with... Lesions and chondrocyte stromelysin synthesis in experimental osteoarthritis ( OA ) subdermal changes, forming depressions in the area.! Card ) is nearly complete within 12 hours care must be exercised not to exceed recommended doses in.... 10–20 mg/kg once daily for 3 days, alternatively 400–600 mg/m 2 daily. Required for short term management of severe, acute conditions blood levels are,... Or 80 mg of methylprednisolone acetate injectable suspension may result in dermal and/or subdermal changes, forming in. Healthcare professional 1.2 ml skin at the injection site producing glucocorticoid effects for 3-4 weeks in some...., sparingly soluble in acetone, alcohol, chloroform, and inflammatory conditions sectioned by stab! Be given as an intravenous infusion of the right knee was sectioned by a wound. Rss Reader acute conditions Hikma presentation: Solvent quantity ( WFI ): blindness first dorsal of! Injections ( steroid card ) recommended doses in injections mg. 1.2 ml is... ): blindness whenever possible in scope, these drugs will include normal. Being treated patients noted over the ensuing weeks no longer formulated with this excipient due to concerns possible. ; Related Products ; purchase injections in knee osteoarthritis: a randomized, double-blinded 24-week... It is slowly absorbed from the IM injection site ; Peer-Reviewed Papers ; Related Products ;.... Solvent quantity ( WFI ): Final solution concentration: 40 mg. ml. Acetate intraarticular injections in knee osteoarthritis: a randomized, double-blinded, 24-week study Documentation ; &!